Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Identifieur interne : 007F21 ( Main/Exploration ); précédent : 007F20; suivant : 007F22Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Auteurs : Peter Baluk [États-Unis] ; Tuomas Tammela [Finlande] ; Erin Ator [États-Unis] ; Natalya Lyubynska [États-Unis] ; Marc G. Achen [Australie] ; Daniel J. Hicklin [États-Unis] ; Michael Jeltsch [Finlande] ; Tatiana V. Petrova [Finlande] ; Bronislaw Pytowski [États-Unis] ; Steven A. Stacker [Australie] ; Seppo Yl Herttuala [Finlande] ; David G. Jackson [Royaume-Uni] ; Kari Alitalo [Finlande] ; Donald M. Mcdonald [États-Unis]Source :
- Journal of Clinical Investigation [ 0021-9738 ] ; 2005.
Descripteurs français
- KwdFr :
- Adenoviridae, Animaux, Bronches (), Bronches (anatomopathologie), Bronches (microbiologie), Bronches (métabolisme), Cellules dendritiques (anatomopathologie), Cellules dendritiques (métabolisme), Facteur de croissance endothéliale vasculaire de type C (génétique), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Facteur de croissance endothéliale vasculaire de type D (génétique), Facteur de croissance endothéliale vasculaire de type D (métabolisme), Facteurs de croissance endothéliale, Granulocytes neutrophiles (anatomopathologie), Granulocytes neutrophiles (métabolisme), Hyperplasie (anatomopathologie), Hyperplasie (microbiologie), Infections à Mycoplasma (anatomopathologie), Infections à Mycoplasma (métabolisme), Inflammation (anatomopathologie), Inflammation (génétique), Inflammation (microbiologie), Inflammation (métabolisme), Macrophages alvéolaires (anatomopathologie), Macrophages alvéolaires (métabolisme), Maladie chronique, Muqueuse respiratoire (anatomopathologie), Muqueuse respiratoire (microbiologie), Muqueuse respiratoire (métabolisme), Mycoplasma pulmonis, Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (métabolisme), Néovascularisation pathologique (anatomopathologie), Néovascularisation pathologique (génétique), Néovascularisation pathologique (microbiologie), Néovascularisation pathologique (métabolisme), Obstruction des voies aériennes, Oedème pulmonaire (anatomopathologie), Oedème pulmonaire (génétique), Oedème pulmonaire (microbiologie), Régulation de l'expression des gènes (génétique), Souris, Souris de lignée C3H, Transduction du signal (génétique), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Bronches, Cellules dendritiques, Granulocytes neutrophiles, Hyperplasie, Infections à Mycoplasma, Inflammation, Macrophages alvéolaires, Muqueuse respiratoire, Noeuds lymphatiques, Néovascularisation pathologique, Oedème pulmonaire, Vaisseaux lymphatiques.
- génétique : Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Inflammation, Néovascularisation pathologique, Oedème pulmonaire, Régulation de l'expression des gènes, Transduction du signal.
- microbiologie : Bronches, Hyperplasie, Inflammation, Muqueuse respiratoire, Néovascularisation pathologique, Oedème pulmonaire.
- métabolisme : Bronches, Cellules dendritiques, Facteur de croissance endothéliale vasculaire de type C, Facteur de croissance endothéliale vasculaire de type D, Granulocytes neutrophiles, Infections à Mycoplasma, Inflammation, Macrophages alvéolaires, Muqueuse respiratoire, Noeuds lymphatiques, Néovascularisation pathologique, Vaisseaux lymphatiques.
- Adenoviridae, Animaux, Bronches, Facteurs de croissance endothéliale, Maladie chronique, Mycoplasma pulmonis, Obstruction des voies aériennes, Souris, Souris de lignée C3H.
English descriptors
- KwdEn :
- Adenoviridae, Airway Obstruction, Animals, Bronchi (blood supply), Bronchi (metabolism), Bronchi (microbiology), Bronchi (pathology), Chronic Disease, Dendritic Cells (metabolism), Dendritic Cells (pathology), Endothelial Growth Factors, Gene Expression Regulation (genetics), Hyperplasia (microbiology), Hyperplasia (pathology), Inflammation (genetics), Inflammation (metabolism), Inflammation (microbiology), Inflammation (pathology), Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Macrophages, Alveolar (metabolism), Macrophages, Alveolar (pathology), Mice, Mice, Inbred C3H, Mycoplasma Infections (metabolism), Mycoplasma Infections (pathology), Mycoplasma pulmonis, Neovascularization, Pathologic (genetics), Neovascularization, Pathologic (metabolism), Neovascularization, Pathologic (microbiology), Neovascularization, Pathologic (pathology), Neutrophils (metabolism), Neutrophils (pathology), Pulmonary Edema (genetics), Pulmonary Edema (microbiology), Pulmonary Edema (pathology), Respiratory Mucosa (metabolism), Respiratory Mucosa (microbiology), Respiratory Mucosa (pathology), Signal Transduction (genetics), Vascular Endothelial Growth Factor C (genetics), Vascular Endothelial Growth Factor C (metabolism), Vascular Endothelial Growth Factor D (genetics), Vascular Endothelial Growth Factor D (metabolism).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- chemical , metabolism : Vascular Endothelial Growth Factor C, Vascular Endothelial Growth Factor D.
- chemical : Endothelial Growth Factors.
- blood supply : Bronchi.
- genetics : Gene Expression Regulation, Inflammation, Neovascularization, Pathologic, Pulmonary Edema, Signal Transduction.
- metabolism : Bronchi, Dendritic Cells, Inflammation, Lymph Nodes, Lymphatic Vessels, Macrophages, Alveolar, Mycoplasma Infections, Neovascularization, Pathologic, Neutrophils, Respiratory Mucosa.
- microbiology : Bronchi, Hyperplasia, Inflammation, Neovascularization, Pathologic, Pulmonary Edema, Respiratory Mucosa.
- pathology : Bronchi, Dendritic Cells, Hyperplasia, Inflammation, Lymph Nodes, Lymphatic Vessels, Macrophages, Alveolar, Mycoplasma Infections, Neovascularization, Pathologic, Neutrophils, Pulmonary Edema, Respiratory Mucosa.
- Adenoviridae, Airway Obstruction, Animals, Chronic Disease, Mice, Mice, Inbred C3H, Mycoplasma pulmonis.
Abstract
Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent lymphatic vessels grow to compensate for increased leakage during inflammation and what drives the lymphangiogenesis that does occur. We addressed these issues in mouse models of (a) chronic respiratory tract infection with
Url:
DOI: 10.1172/JCI200522037
PubMed: 15668734
PubMed Central: 544601
Affiliations:
- Australie, Finlande, Royaume-Uni, États-Unis
- Angleterre, Californie, Oxfordshire, Uusimaa, État de New York
- Helsinki, Oxford
- Université d'Helsinki, Université d'Oxford
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Le document en format XML
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Stacker</name><affiliation wicri:level="1"><nlm:aff id="N0x8cc46c0.0x9efa998">Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name><affiliation wicri:level="1"><nlm:aff id="N0x8cc46c0.0x9efa998">A.I. Virtanen Institute and Department of Medicine, University of Kuopio, Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>A.I. Virtanen Institute and Department of Medicine, University of Kuopio, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. 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Mcdonald</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15668734</idno><idno type="pmc">544601</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544601</idno><idno type="RBID">PMC:544601</idno><idno type="doi">10.1172/JCI200522037</idno><date when="2005">2005</date><idno type="wicri:Area/Pmc/Corpus">000B63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B63</idno><idno 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Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name><affiliation wicri:level="4"><nlm:aff id="N0x8cc46c0.0x9efa998">Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Ator, Erin" sort="Ator, Erin" uniqKey="Ator E" first="Erin" last="Ator">Erin Ator</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lyubynska, Natalya" sort="Lyubynska, Natalya" uniqKey="Lyubynska N" first="Natalya" last="Lyubynska">Natalya Lyubynska</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name><affiliation wicri:level="1"><nlm:aff id="N0x8cc46c0.0x9efa998">Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Hicklin, Daniel J" sort="Hicklin, Daniel J" uniqKey="Hicklin D" first="Daniel J." last="Hicklin">Daniel J. Hicklin</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">ImClone Systems Inc., New York, New York, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>ImClone Systems Inc., New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><affiliation wicri:level="4"><nlm:aff id="N0x8cc46c0.0x9efa998">Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><affiliation wicri:level="4"><nlm:aff id="N0x8cc46c0.0x9efa998">Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">ImClone Systems Inc., New York, New York, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>ImClone Systems Inc., New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name><affiliation wicri:level="1"><nlm:aff id="N0x8cc46c0.0x9efa998">Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name><affiliation wicri:level="1"><nlm:aff id="N0x8cc46c0.0x9efa998">A.I. Virtanen Institute and Department of Medicine, University of Kuopio, Kuopio, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>A.I. Virtanen Institute and Department of Medicine, University of Kuopio, Kuopio</wicri:regionArea><wicri:noRegion>Kuopio</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name><affiliation wicri:level="4"><nlm:aff id="N0x8cc46c0.0x9efa998">University of Oxford, Nuffield Department of Medicine/Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>University of Oxford, Nuffield Department of Medicine/Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><affiliation wicri:level="4"><nlm:aff id="N0x8cc46c0.0x9efa998">Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki, Finland.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Finlande</country><wicri:regionArea>Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName><orgName type="university">Université d'Helsinki</orgName></affiliation></author><author><name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name><affiliation wicri:level="2"><nlm:aff id="N0x8cc46c0.0x9efa998">Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Clinical Investigation</title><idno type="ISSN">0021-9738</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae</term><term>Airway Obstruction</term><term>Animals</term><term>Bronchi (blood supply)</term><term>Bronchi (metabolism)</term><term>Bronchi (microbiology)</term><term>Bronchi (pathology)</term><term>Chronic Disease</term><term>Dendritic Cells (metabolism)</term><term>Dendritic Cells (pathology)</term><term>Endothelial Growth Factors</term><term>Gene Expression Regulation (genetics)</term><term>Hyperplasia (microbiology)</term><term>Hyperplasia (pathology)</term><term>Inflammation (genetics)</term><term>Inflammation (metabolism)</term><term>Inflammation (microbiology)</term><term>Inflammation (pathology)</term><term>Lymph Nodes (metabolism)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Macrophages, Alveolar (metabolism)</term><term>Macrophages, Alveolar (pathology)</term><term>Mice</term><term>Mice, Inbred C3H</term><term>Mycoplasma Infections (metabolism)</term><term>Mycoplasma Infections (pathology)</term><term>Mycoplasma pulmonis</term><term>Neovascularization, Pathologic (genetics)</term><term>Neovascularization, Pathologic (metabolism)</term><term>Neovascularization, Pathologic (microbiology)</term><term>Neovascularization, Pathologic (pathology)</term><term>Neutrophils (metabolism)</term><term>Neutrophils (pathology)</term><term>Pulmonary Edema (genetics)</term><term>Pulmonary Edema (microbiology)</term><term>Pulmonary Edema (pathology)</term><term>Respiratory Mucosa (metabolism)</term><term>Respiratory Mucosa (microbiology)</term><term>Respiratory Mucosa (pathology)</term><term>Signal Transduction (genetics)</term><term>Vascular Endothelial Growth Factor C (genetics)</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Vascular Endothelial Growth Factor D (genetics)</term><term>Vascular Endothelial Growth Factor D (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenoviridae</term><term>Animaux</term><term>Bronches ()</term><term>Bronches (anatomopathologie)</term><term>Bronches (microbiologie)</term><term>Bronches (métabolisme)</term><term>Cellules dendritiques (anatomopathologie)</term><term>Cellules dendritiques (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type C (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Facteur de croissance endothéliale vasculaire de type D (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type D (métabolisme)</term><term>Facteurs de croissance endothéliale</term><term>Granulocytes neutrophiles (anatomopathologie)</term><term>Granulocytes neutrophiles (métabolisme)</term><term>Hyperplasie (anatomopathologie)</term><term>Hyperplasie (microbiologie)</term><term>Infections à Mycoplasma (anatomopathologie)</term><term>Infections à Mycoplasma (métabolisme)</term><term>Inflammation (anatomopathologie)</term><term>Inflammation (génétique)</term><term>Inflammation (microbiologie)</term><term>Inflammation (métabolisme)</term><term>Macrophages alvéolaires (anatomopathologie)</term><term>Macrophages alvéolaires (métabolisme)</term><term>Maladie chronique</term><term>Muqueuse respiratoire (anatomopathologie)</term><term>Muqueuse respiratoire (microbiologie)</term><term>Muqueuse respiratoire (métabolisme)</term><term>Mycoplasma pulmonis</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (métabolisme)</term><term>Néovascularisation pathologique (anatomopathologie)</term><term>Néovascularisation pathologique (génétique)</term><term>Néovascularisation pathologique (microbiologie)</term><term>Néovascularisation pathologique (métabolisme)</term><term>Obstruction des voies aériennes</term><term>Oedème pulmonaire (anatomopathologie)</term><term>Oedème pulmonaire (génétique)</term><term>Oedème pulmonaire (microbiologie)</term><term>Régulation de l'expression des gènes (génétique)</term><term>Souris</term><term>Souris de lignée C3H</term><term>Transduction du signal (génétique)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Vascular Endothelial Growth Factor C</term><term>Vascular Endothelial Growth Factor D</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Endothelial Growth Factors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Bronches</term><term>Cellules dendritiques</term><term>Granulocytes neutrophiles</term><term>Hyperplasie</term><term>Infections à Mycoplasma</term><term>Inflammation</term><term>Macrophages alvéolaires</term><term>Muqueuse respiratoire</term><term>Noeuds lymphatiques</term><term>Néovascularisation pathologique</term><term>Oedème pulmonaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Bronchi</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation</term><term>Inflammation</term><term>Neovascularization, Pathologic</term><term>Pulmonary Edema</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Inflammation</term><term>Néovascularisation pathologique</term><term>Oedème pulmonaire</term><term>Régulation de l'expression des gènes</term><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bronchi</term><term>Dendritic Cells</term><term>Inflammation</term><term>Lymph Nodes</term><term>Lymphatic Vessels</term><term>Macrophages, Alveolar</term><term>Mycoplasma Infections</term><term>Neovascularization, Pathologic</term><term>Neutrophils</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bronches</term><term>Hyperplasie</term><term>Inflammation</term><term>Muqueuse respiratoire</term><term>Néovascularisation pathologique</term><term>Oedème pulmonaire</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bronchi</term><term>Hyperplasia</term><term>Inflammation</term><term>Neovascularization, Pathologic</term><term>Pulmonary Edema</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bronches</term><term>Cellules dendritiques</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Facteur de croissance endothéliale vasculaire de type D</term><term>Granulocytes neutrophiles</term><term>Infections à Mycoplasma</term><term>Inflammation</term><term>Macrophages alvéolaires</term><term>Muqueuse respiratoire</term><term>Noeuds lymphatiques</term><term>Néovascularisation pathologique</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bronchi</term><term>Dendritic Cells</term><term>Hyperplasia</term><term>Inflammation</term><term>Lymph Nodes</term><term>Lymphatic Vessels</term><term>Macrophages, Alveolar</term><term>Mycoplasma Infections</term><term>Neovascularization, Pathologic</term><term>Neutrophils</term><term>Pulmonary Edema</term><term>Respiratory Mucosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adenoviridae</term><term>Airway Obstruction</term><term>Animals</term><term>Chronic Disease</term><term>Mice</term><term>Mice, Inbred C3H</term><term>Mycoplasma pulmonis</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adenoviridae</term><term>Animaux</term><term>Bronches</term><term>Facteurs de croissance endothéliale</term><term>Maladie chronique</term><term>Mycoplasma pulmonis</term><term>Obstruction des voies aériennes</term><term>Souris</term><term>Souris de lignée C3H</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent lymphatic vessels grow to compensate for increased leakage during inflammation and what drives the lymphangiogenesis that does occur. We addressed these issues in mouse models of (a) chronic respiratory tract infection with <italic>Mycoplasma pulmonis</italic> and (b) adenoviral transduction of airway epithelium with VEGF family growth factors. Blood vessel remodeling and lymphangiogenesis were both robust in infected airways. Inhibition of VEGFR-3 signaling completely prevented the growth of lymphatic vessels but not blood vessels. Lack of lymphatic growth exaggerated mucosal edema and reduced the hypertrophy of draining lymph nodes. Airway dendritic cells, macrophages, neutrophils, and epithelial cells expressed the VEGFR-3 ligands VEGF-C or VEGF-D. Adenoviral delivery of either VEGF-C or VEGF-D evoked lymphangiogenesis without angiogenesis, whereas adenoviral VEGF had the opposite effect. After antibiotic treatment of the infection, inflammation and remodeling of blood vessels quickly subsided, but lymphatic vessels persisted. Together, these findings suggest that when lymphangiogenesis is impaired, airway inflammation may lead to bronchial lymphedema and exaggerated airflow obstruction. Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases.</p></div></front></TEI><affiliations><list><country><li>Australie</li><li>Finlande</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Californie</li><li>Oxfordshire</li><li>Uusimaa</li><li>État de New York</li></region><settlement><li>Helsinki</li><li>Oxford</li></settlement><orgName><li>Université d'Helsinki</li><li>Université d'Oxford</li></orgName></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Baluk, Peter" sort="Baluk, Peter" uniqKey="Baluk P" first="Peter" last="Baluk">Peter Baluk</name></region><name sortKey="Ator, Erin" sort="Ator, Erin" uniqKey="Ator E" first="Erin" last="Ator">Erin Ator</name><name sortKey="Hicklin, Daniel J" sort="Hicklin, Daniel J" uniqKey="Hicklin D" first="Daniel J." last="Hicklin">Daniel J. Hicklin</name><name sortKey="Lyubynska, Natalya" sort="Lyubynska, Natalya" uniqKey="Lyubynska N" first="Natalya" last="Lyubynska">Natalya Lyubynska</name><name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name><name sortKey="Pytowski, Bronislaw" sort="Pytowski, Bronislaw" uniqKey="Pytowski B" first="Bronislaw" last="Pytowski">Bronislaw Pytowski</name></country><country name="Finlande"><region name="Uusimaa"><name sortKey="Tammela, Tuomas" sort="Tammela, Tuomas" uniqKey="Tammela T" first="Tuomas" last="Tammela">Tuomas Tammela</name></region><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name><name sortKey="Jeltsch, Michael" sort="Jeltsch, Michael" uniqKey="Jeltsch M" first="Michael" last="Jeltsch">Michael Jeltsch</name><name sortKey="Petrova, Tatiana V" sort="Petrova, Tatiana V" uniqKey="Petrova T" first="Tatiana V." last="Petrova">Tatiana V. Petrova</name><name sortKey="Yl Herttuala, Seppo" sort="Yl Herttuala, Seppo" uniqKey="Yl Herttuala S" first="Seppo" last="Yl Herttuala">Seppo Yl Herttuala</name></country><country name="Australie"><noRegion><name sortKey="Achen, Marc G" sort="Achen, Marc G" uniqKey="Achen M" first="Marc G." last="Achen">Marc G. Achen</name></noRegion><name sortKey="Stacker, Steven A" sort="Stacker, Steven A" uniqKey="Stacker S" first="Steven A." last="Stacker">Steven A. Stacker</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Jackson, David G" sort="Jackson, David G" uniqKey="Jackson D" first="David G." last="Jackson">David G. Jackson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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